I-Hot-melt extrusion (HME) inqubo esunguliwe ebisetshenziswa kusukela ekuqaleni kwawo-1930, ikakhulukazi ekukhiqizeni amapulasitiki…
Kunezinhlobo ezimbili zama-extruder: ama-extruder angama-single kanye namawele angama-screw.Ama-scruder angama-screw single asetshenziselwa ngokuyinhloko ukuncibilikisa kanye nokudlulisa ama-polymers ukuze awakhiphe abe yizimo eziqhubekayo, kuyilapho ama-extruder angamawele angamawele asetshenziselwa ama-polymers axubayo anezinto ezengeziwe (imibala, izihlungi, iziqinisi, nama-API), kanye nokuqeda amandla.Ekukhiqizeni ukwakheka kwemithi, okudinga ukuxutshwa kwe-homo-geneous kanye nokungaguquguquki kwezithako eziningi zokwakha, i-twin screw extruder iyakhethwa ngoba ukuzungezisa kwezikulufu ze-inter-meshing kunikeza ukuxuba okungcono ukuze kukhiqizwe okuqinile okulinganayo okuqukethe izinhlayiya ze-API ezihlakazeke kahle, noma isixazululo esiqinile se-API ku-polymer.Lokhu kungathuthukisa izinga lokuqedwa kanye nekhono le-bioavail lokubunjwa kwe-API engancibiliki kahle emanzini.I-API yokusabalalisa ngendlela efanayo iphinde ibe yimfuneko yangaphambilini yokukhiqizwa kwemishini ehlanza izidakamizwa enokuphindaphindeka kwe-intra- kanye ne-inter-batch ye-ki-netics yokukhishwa kwezidakamizwa.
Ukuncibilika kufezwa ngokushisisa okuyi-fric-tional ngaphakathi komgqomo, kanye nama-twin-screw extruder, njengoba izinto ezisetshenziswayo zigunda phakathi kwezikulufu ezizungezisayo naphakathi kwezikulufu nodonga lombhobho njengoba zihanjiswa.Umgqomo ubuye ushiswe ngama-heaters afakwe emgqonyeni, noma upholiswe ngamanzi.Amazinga okushisa esigaba somgqomo ajwayele ukwenziwa ngcono ukuze i-viscosity yokuncibilika ibe phansi ngokwanele ukuvumela ukudluliswa komgqomo nokuxubana okufanele, kuyilapho kugcina izinga lokushisa liphansi ngokwanele ukugwema ukuwohloka okushisayo kwezinto.
Izikulufu ze-twin screw extruder ngokuvamile zihlinzeka ngezinhlobo ezahlukene zokuxuba nokudlulisa izimo ezindaweni ezihlukahlukene emgqonyeni.Ngesikhathi sokuthuthukiswa komkhiqizo, izikulufu zemodular ezinama-elementi amaningi afakwe ku-shaft evamile, zivumela ukuthungwa kanye nokwenza kahle kwedizayini yesikulufu somkhiqizo ngamunye.Izingxenye zesikulufu zingaklanywa ukwenza umsebenzi wokunciphisa usayizi wezinhlayiyana, ukuxuba nokudlulisa imisebenzi.Ubude besikulufu ngokuhlobene nobubanzi bomphongolo (isilinganiso se-L/D) bukhethwa ukuze kuthuthukiswe izinga lokuxutshwa kanye nenani lezindawo ezidingekayo ukuze kuzuzwe umphumela wokugcina womkhiqizo.Isibonelo sesikulufu esiphelele se-modular.Izikulufu zokukhiqiza zocezu olulodwa zingase zakhiwe ngendlela efanayo nezikulufu zokuthuthuka, kodwa kulula ukuzihlanza ukuze zihambisane ne-cGMP.
Isikhathi sokuthumela: Jun-03-2017